Frank van Leth

Frank van Leth

  • Associate Professor, Department of Global Health, Amsterdam UMC, University of Amsterdam
  • Epidemiologist

Trained as a physician at the University of Amsterdam, Associate Professor Frank van Leth worked for four years as a Medical Officer in-charge at the 170-bed Misikhu Mission Hospital in Kenya. He pursued a Master’s degree in epidemiology at the prestigious London School of Hygiene and Tropical Medicine, after which he worked as an epidemiologist at several institutions.

Currently, he is a Senior Scientist at the Amsterdam Institute for Global Health and Development, and the Department of Global Health at the Academic Medical Center in Amsterdam. He has an extensive research portfolio in the fields of HIV and tuberculosis. He has a personal affinity for novel, yet contextually relevant, methodological approaches for capturing public health needs and designing appropriate interventions.

Van Leth is involved in teaching at the Bachelor, Master, and PhD level, where he focuses on epidemiological concepts and statistical methodology for the field of Global Health.

Van Leth is the current chair of TBnet, a European Consortium with over 650 members dedicated to collaborative basic, translational, clinical, and applied TB research. Other current international collaborations include Padjadjaran University, Jakarta, Indonesia, Institute of Tropical Medicine, Antwerp, Belgium, and Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.

His recent research projects in Indonesia and the Netherlands focus on developing and applying new tools to measure the prevalence of infection and drug resistance in a timely and reliable fashion, making the results rapidly available for decision-makers and clinicians alike.

He is an Associate Editor of the Journal of Tuberculosis and Lung Diseases, and the Journal of Epidemiology and Community Health.

View Frank’s publications (PubMed)


Treatment Outcomes in Multidrug-Resistant Tuberculosis.
Günther G, Lange C, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, Magis-Escurra C, McLaughlin AM, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, van Leth F; for TBNET.
N Engl J Med. 2016 Sep 15;375(11):1103-5. doi: 10.1056/NEJMc1603274

Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure.
Dedicoat MJ, Günther G, Crudu V, Duarte R, Gualano G, Magis-Escurra C, Rumetshofer R, Skrahina A, Spinu V, Tiberi S, Viiklepp P, van Leth F, Lange C; TBNET.
Am J Respir Crit Care Med. 2017 Mar 21. doi: 10.1164/rccm.201612-2585LE.

Rapid assessment of antimicrobial resistance prevalence using a Lot Quality Assurance sampling approach.
van Leth F, den Heijer C, Beerepoot M, Stobberingh E, Geerlings S, Schultsz C.
Future Microbiol. 2017 Apr;12:369-377. doi: 10.2217/fmb-2016-0170.

Antimicrobial drug resistance among clinically relevant bacterial isolates in sub-Saharan Africa: a systematic review.
Leopold SJ, van Leth F, Tarekegn H, Schultsz C.
J Antimicrob Chemother. 2014 Sep;69(9):2337-53. doi: 10.1093/jac/dku176.


Multidrug resistance among new tuberculosis cases: detecting local variation through lot quality-assurance sampling.
Hedt BL, van Leth F, Zignol M, Cobelens F, van Gemert W, Nhung NV, Lyepshina S, Egwaga S, Cohen T.
Epidemiology. 2012 Mar;23(2):293-300. doi: