Jacquline Msefula is currently based in Malawi and working under the Innovative Monitoring in Paediatrics in Low-resource settings: an Aid to save lives? (IMPALA study) as the Biomedical PhD fellow. Her core intellectual and professional goal has always been in the development of effective, user-friendly, reliable scientific tools, methods and knowledge. She was working with the Malawi-Liverpool Wellcome Trust for the past 6 years in the evaluation of Streptococcus PCV13 Vaccine, carriage and antimicrobial resistance in Children to Monitoring SARS-COVID patterns in Malawi implementing and improving the laboratory methodology of detection of pathogens and host immunological response. The IMPALA study has offered her an opportunity to be part of the team looking into the use of biomarkers in a predictive algorithm to help in predicting critical illness in Children. As part of her PhD, She is looking into the roles of the biomarkers of interest and how can they be used to predict disease outcome and differentiate between bacterial and viral infections in Malawi.