Protecting Pyrazinamide and Fluoroquinolones for successful multi-drug resistant tuberculosis (MDR-TB) treatment
The objective of the study is to assess the frequency of additional drug resistance under sub-optimal treatment for drug-resistant tuberculosis.
Even when correctly managed, following international and national guidelines, due to the complexity of (tuberculosis) TB diagnostics and delay of the identification of resistance, a proportion of patients will initially receive inappropriate first line therapy. The precise contribution this under-treatment makes to the generation of resistance is unknown.
We will study a cohort from Moldova and Belarus, countries with a high frequency of drug resistance in TB patients.
We will recruit patients who will start directly on appropriate therapy and a matched group that will initially receive inappropriate therapy. Paired sputum cultures obtained at the time of diagnosis, and at the moment drug resistance is detected will be assessed for additional drug resistance. Results will be directly relevant for future treatment and monitoring guidelines.
AIGHD Research Lead
University Hospital Groningen
TB treatment center Belarus
TB treatment center Moldova
Richard Anthony (email@example.com)