It takes more than a sensitive test to find more tuberculosis cases

Authored by: Trajman A, Cobelens F.
In: Lancet Infect Dis, 2017 5 Jan.

Of the 9·6 million people estimated to have developed tuberculosis in 2014, only 63% of cases were reported.1 This gap partly reflects low rates of case detection and calls for models of intensified case finding at the community level based on effective and feasible screening strategies and technologies.

Ankeiler: In this comment Anete Trajman and Frank Cobelens discuss the limitations of pragmatic trials of enhanced/active case finding for tuberculosis, in particular the sensitivity of the results to variation in existing practice and the importance of cost-effectiveness.