Rotabiome

The influence of the intestinal microbiome on infant rotavirus vaccine responses in rural Ghana and urban Pakistan.

Black Girl Hand and Abdomen

Objective

To test the hypothesis that the differential presence of immune-stimulating intestinal microbes influences oral rotavirus vaccine efficacy in infants.


Description

Rotavirus is the leading cause of diarrhea-related death in children worldwide, with 95% of rotavirus deaths occurring in low-income countries in Africa and Asia.  Rotavirus vaccines  have the potential to dramatically reduce the morbidity and mortality caused by rotavirus infection, however rotavirus vaccines demonstrate significantly lower efficacy in low-income countries.

 

Understanding the pathophysiology behind this diminished efficacy is critical, as even small improvements in efficacy could increase the number of childrens’ lives saved by the vaccine by hundreds of thousands over the next 15 years.

 

One of several explanations for these differences in vaccine efficacy is that the infant intestinal microbiota may be modulating an infant’s immune response to the enteric RVV. We hypothesized that the composition of the intestinal microbiota is influencing RVV response, that RV vaccine responders have different intestinal microbes as compared to non-responders and that these dissimilarities contribute to the decreased efficacy of RVV found in Africa and Asia.


AIGHD Research Lead

Dr. Vanessa Harris


Funders

This research is funded in part by the Bill & Melinda Gates Foundation; GAVI, the Vaccine Alliance, GlaxoSmithKline Biological SA (GSK) and the Netherlands Organization for Scientific Research [Spinoza Grant 2008 to WMdV].


Countries

Pakistan
Ghana