16 May Article J Infectious Diseases

Posted at 19:03h in News, Publications by

Tuberculosis Relapse in Vietnam Is Significantly Associated With Mycobacterium tuberculosis Beijing Genotype Infections.

In this paper PhD student May Nguyet Thu Huyen presents a molecular epidemiology study of the effects of Mycobacterium tuberculosis genotype on tuberculosis relapse rates in Vietnam. She finds that patients infected with the Beijing genotype, which constitutes one third of all circulating M. tuberculosis strains in Vietnam and has been associated with multidrug resistant tuberculosis in various studies, have an increased risk of tuberculosis relapse during the first 18 months after succesful completion of standard first-line tuberculosis treatment. This association is independent of drug resistance, and may explain part of the rise in Beijing genotype infections seen in several countries worldwide.

 

Tuberculosis Relapse in Vietnam Is Significantly Associated With Mycobacterium tuberculosis Beijing Genotype Infections
Authors: Huyen MN, Buu TN, Tiemersma E, Lan NT, Dung NH, Kremer K, Soolingen DV, Cobelens FG.
In: J Infect Dis. 2013 May;207(10):1516-24. doi: 10.1093/infdis/jit048. Epub 2013 Feb 13
Link to abstract: PubMed